Werner syndrome RecQ helicase-IN-1( —— )

Catalog No. M36443 CAS No. 2869954-34-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Werner syndrome RecQ helicase-IN-1
Note

Research use only, not for human use.
Brief Description

Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
Description

Werner syndrome RecQ helicase-IN-1 (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research.
In Vitro

Werner syndrome RecQ helicase-IN-1 (example 42) has an IC50 value of 100 nM for WRN ATPase and GI50 values of 50 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively.
In Vivo

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Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis
Research Area

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Indication

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CAS Number

2869954-34-5
Formula Weight

702.08
Molecular Formula

C31H31ClF3N9O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (142.43 mM; Ultrasonic )
SMILES

C(C(NC1=C(Cl)C=C(C(F)(F)F)C=C1)=O)N2C=3N(C(=O)C(=C2CC)N4CCN(C(=O)C=5C(O)=C(C)N=CN5)CC4)N=C(N3)C=6CCOCC6
Chemical Name

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1. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060

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